Table 2

Serum pharmacokinetic indices for tobramycin

Group AGroup Bp value
Serum peak on day 1 (mg/l)13.2 (7.1)42.5 (11.2)< 0.001
Serum peak on day 14 (mg/l)12.4  (3.9)39.4  (20)< 0.001
Serum trough on day 1 (mg/l)1.1  (0.8)0.3  (0.2)< 0.01
Serum trough on day 14 (mg/l)0.9  (0.5)0.4  (0.3)< 0.01
Total clearance (ml/h/kg)3.73  (1.37)4.73  (2.43)0.4
Volume of distribution (l/kg)0.54  (0.88)0.97  (0.44)0.6
Area under the curve (mg.h/l)121.5  (42)98.6  (32.5)0.6
  • Group A, thrice daily infusions of tobramycin; group B, once daily infusions of tobramycin. Values are mean (SD).