Table 2

Clinical categories of the paediatric HIV classification system (adapted from MMWR 1994;43:RR1-12)

Category N: asymptomatic
Category A: mildly sympomatic
 At least two of: lymphadenopathy, hepatomegaly, splenomegaly, parotitis, rash, ear, nose and throat infections
Category B: moderately sympomatic
 Single episode of a severe bacterial infection
 Lymphocytic interstitial pneumonitis
 Anaemia, neutropenia, thrombocytopenia
 Cardiomyopathy, nephropathy, hepatitis, diarrhoea
 Candidiasis, severe varicella/zoster or herpes simplex virus
Category C: severely sympomatic (AIDS)
 Two serious bacterial infections
 Encephalopathy (acquired microcephaly, cognitive delay, abnormal neurology)
 Wasting syndrome (severe failure to thrive or downward crossing two weight centiles)
 Opportunistic infections (PCP, cytomegalovirus, toxoplasmosis, disseminated fungal infections)
 Disseminated mycobacterial disease
 Cancer (Kaposi’s sarcoma, lymphomas)