Group data showing the cardiovascular effects of intravenous midazolam. Data are expressed as mean (SE)
| Haemodynamic variable | Prebolus (T0) | On intravenous infusion | |||
|---|---|---|---|---|---|
| 15 min (T1) | 1 hour (T2) | ||||
| Cardiac index (l/min/m2) | 5.1 (0.5) | 3.7 (0.4)† | 4.6 (0.4)§ | ||
| Oxygen consumption (ml/min/m2) | 266 (23) | 222 (20)† | 243 (24) | ||
| Mixed venous oxygen content (ml/100 ml blood) | 12.3 (0.9) | 11.6 (0.7)2-150 | 12.2 (0.7)‡ | ||
| Heart rate (beats/min) | 125 (9) | 123 (8) | 130 (8)§ ¶ | ||
| Stroke volume (ml/m2) | 41.8 (6.5) | 33.1 (4.9)† | 39.6 (4.7) | ||
| Systolic blood pressure (mm Hg) | 103 (7.3) | 83 (6.0)† | 89 (3.7) | ||
| Diastolic blood pressure (mm Hg) | 55 (3.5) | 45 (3.2)2-150 | 50 (2.2) | ||
| Mean arterial pressure (mm Hg) | 70 (4.7) | 58 (3.9)† | 62 (2.4) | ||
| Right atrial pressure (mm Hg) | 11 (1.1) | 10 (1.0) | 11 (0.8) | ||
| SVRI (units/m2) | 11.7 (1.2) | 13.5 (1.2) | 12.2 (1.8) | ||
| PVRI (units/m2) | 0.96 (0.3) | 1.63 (0.5) | 1.25 (0.5) | ||
PVRI = pulmonary vascular resistance index; SVRI = systemic vascular resistance index.
↵2-150 Haemodynamic change between T0 and T1: p < 0.05; † haemodynamic change between T0 and T1: p ≤ 0.01; ‡ haemodynamic change between T0 and T2 : p < 0.05; § haemodynamic change between T1 and T2: p ≤ 0.01; ¶ haemodynamic change between T0 and T2: p < 0.05.