Table 1

Case reports of infantile vitamin B-12 deficiency in the literature

AuthorNo of patientsAetiology of vitamin B-12 deficiencyAge at diagnosis (months)Haemoglobin
(< 100 g/l)
Neurological symptomsComatoseNeurodevelopment at follow up
Jadhav et al 5 64 MPA, 2 vegan7-126/66/65/6No follow up
Pearson and Turner10 1MPA321/11/11/1Abnormal at 6 years
Wighton et al 7 1Vegan91/11/11/1Abnormal at 12 years
Higginbottom et al 4 1Vegan61/11/11/1No follow up
Close20 1Vegan121/11/11/1No follow up
Sklar9 1Vegan71/11/1Normal at 13 months
Stollhoff and Schulte6 1Vegan141/11/11/1Abnormal at 26 months
McPhee et al 14 1MPA51/11/10/1Normal at 8 years
Kühne et al 8 1Vegan91/11/11/1Normal at 13 months
Michaud et al 12 21 MPA, 1 vegan20/20/20/2Normal at 14 months and 2 years
Graham et al 3 63 MPA, 3 vegan8-154/66/66/62 normal at 9 and 10 years,
 2 abnormal at 4 and 5 years
Almadan et al 2 2Vegan5, 242/22/22/2No follow up
Grange and Finlay13 1Gastric bypass101/11/11/1Normal at 12.5 months
Our patient1Vegan141/11/11/1Abnormal at 26 months
  • MPA = maternal penicious anaemia; vegan = strictly vegetarian (vegan) diet of the mother; gastric bypass = maternal gastric bypass surgery.