Table 1

Clinical and laboratory features of children who had ICP monitoring

Patient No		Age (months)		Pattern of intracranial hypertension1-150		Duration of coma before ICP monitoring (hours)		On admission			During admission		On discharge (CNS sequelae1-160)
Patient No		Age (months)		Pattern of intracranial hypertension1-150		Duration of coma before ICP monitoring (hours)		Adelaide coma scale (V, M, E)1-151	Brain stem signs1-152		Parasite count (per μl)	Haemoglobin (g/l)	On discharge (CNS sequelae1-160)		Lactate (mmol/l)	Episodes of hypoglycaemia	Clinically detected seizures1-154	Brain stem deterioration1-152 (hours after treatment)	Computed tomography1-155	Duration of coma (hours)
1	24	MIH	5	2, 3, 2	No	3090	34	9.7	None	PM × 5	No	N	12	None
2	21	MIH	19	2, 3, 4	No	49 742	49	6.2	None	None	No	N	39	None
3	71	MIH	40	2, 4, 2	No	3848	60	5.8	None	S-GTC	36	—	77	None
4	35	MIH	47	1, 3, 1	Yes	242 880	69	9.6	None	None	18	N	68	None
5	77	MIH	44	2, 3, 4	No	80 340	83	2.7	None	GTC × 1	19	—	49	None
6	26	MIH	10	2, 3, 2	No	800 000	49	9.1	None	PM × 6, PBG × 1	No	—	37	None
7	26	MIH	4	2, 3, 2	No	12 402	33	11.2	None	PM × 11, PBG × 5	No	N	56	None
8	69	MIH	6	2, 3, 2	Yes	3196	81	2.6	None	GTC × 3	No	N	41	None
9	17	MIH	44	2, 3, 1	Yes	1377	83	2.0	None	None	7	N	96	Mild
10	19	MIH	17	2, 3, 2	No	36 580	43	—	None	S-PM	11	N	48	None
11	81	IIH	24	2, 3, 2	Yes	1200	110	1.1	None	S-GTC	19, 36	N	87	Mild
12	51	IIH	15	2, 3, 4	No	45 144	86	2.2	None	None	6	N	36	None
13	36	IIH	6	2, 3, 2	No	739 200	52	2.2	None	None	No	—	32	None
14	23	IIH	42	3, 4, 4	No	10 535	31	11.1	None	PM × 10, PBG × 5	10	—	90	None
15	40	IIH	53	2, 3, 2	No	3060	83	1.4	None	PM × 2	26	—	96	None
16	53	IIH	16	2, 4, 3	No	9200	50	5.1	None	PM × 4	No	BS	36	None
17	84	IIH	16	2, 3, 2	No	15 200	81	0.9	None	S-GTC	No	N	18	None
18	24	IIH	25	2, 3, 3	Yes	4293	48	3.9	None	PBG × 2	No	N	44	None
19	42	IIH	75	2, 3, 2	No	1 108 800	111	1.9	A1-153 + 1	GTC × 2	12, 40	BS	120	None
20	24	SIH	13	2, 3, 2	No	92 520	60	8.2	NA1-153 + 1	GTC × 4	6, 24	BS + H	> 140	Severe
21	30	SIH	25	1, 3, 1	Yes	37 269	132	3.4	A1-153 + 4	PM × 1	15	BS + H	> 140	Severe
22	35	SIH	12	2, 2, 2	Yes	842	99	5.4	A1-153 + 1	None	9	—	—	Died
23	36	SIH	16	1, 1, 1	Yes	310 200	54	8.9	None	None	18, 23, 24	—	—	Died

↵1-150 Patterns of intracranial hypertension defined in the text: MIH = mild, IIH = intermediate, SIH = severe.
↵1-151 Adelaide coma scale: V = verbal, M = motor, E = eye opening.
↵1-152 Brain stem signs: one or more of the following signs: pupillary dilation + sluggish response to light, absent corneal reflexes, minial or absent oculocephalic reflexes, decerebrate posturing.
↵1-154 Seizures: GTC = generalised tonic-clonic, PM = partial motor, S = status, PBG = partial becoming generalised.
↵1-155 Computed tomography appearances: BS = brain swelling as defined by loss of sulci and fissures, with small ventricles and narrow basal cisterns; H = generalised hypodensity, N = normal.
↵1-160 CNS = central nervous system.
↵1-153 A = on admission, NA = not on admission.