Median (and range) of plasma 17-OHP, androstenedione, testosterone, and mean (SE) of growth hormone and IGF-I concentrations in 22 prepubertal and four pubertal children with CAH randomly treated with hydrocortisone, 15 or 25 mg/m2daily for two consecutive six month periods
| 17-OHP (nmol/l) | Androstenedione (nmol/l) | Testosterone (nmol/l) | Growth hormone (μg/l) | IGF-1 (μg/l) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Peak | Increment | < 6 years | 6-12 years | > 12 years | ||||||||
| Hydrocortisone 15 mg/m2 | 13.8 (1.8) (n=50) | 9.6 (2) (n=50) | 93.1 (14.9) (n=16) | 320 (39.9) (n=8) | 265 (25) (n=2) | |||||||
| Prepubertal (n=44) | 113.71-150 (0.5–1207.5) | 3.41-150(0.5–40.2) | 2.5 (0.8–9.1) | |||||||||
| Pubertal (n=8) | 91.7 (6.8–453) | 11 (6.1–41.9) | 4.7 (3.9–6.9) | |||||||||
| Hydrocortiscone 25 mg/m2 | 14.9 (1.5 (n=51) | 6.9 (3) (n=51) | 118.2 (20.6) (n=15) | 310 (36.8) (n=8) | 270 (30) (n=2) | |||||||
| Prepubertal (n=44) | 11.51-150 (0.6–819.9) | 1.61-150(0.1–31.8) | 2.3 (1.2–11.3) | |||||||||
| Pubertal (n=8) | 314.2 (66.5–568.7) | 22.3 (10.5–47.5) | 6.2 (3.5–9.2) | |||||||||
↵1-150 p < 0.05, comparing 15mg/m2 with 25 mg/m2; n refers to the number of determinations.
Reference values: 17–OHP < 3 nmol/l; androstenedione < 1.8 nmol/l; testosterone < 1.7 nmol/l; growth hormone increment > 10 μg/l; IGF–1: < 6 years, 40–180 μg/l; 6–12 years, 70–250 μg/l; >12 years, 100–390 μg/l.