Table 1

Definitions of organ system failure

Cardiac Presence of one or more of the following:
 MAP (mm Hg)
  < 30 (neonate-3 months old)
  < 35 (age 3 months-1 year)
  < 40 (age 1 year - 6 years)
  < 50 (> 6 years)
 Arterial blood pH <7.25 with Paco 2< 6.0 kPa
 Requirement for inotropes more than 10 μg/kg/min dopamine
Respiratory Presence of one or more of the following
 Paco 2 < 6.7 kPa with serum pH < 7.25
 A-ado 2 > 46.7 kPa
 Ventilation index >30
Renal Requirement for renal replacement therapy, for example peritoneal dialysis, haemofiltration and presence of one or moreof the following:
 Urine output: < 0.5 ml/kg/hour for 4 consecutive hours or < 300  ml/m2/24 hours
 Serum creatinine (mmol/l)
  > 0.15 (age day 1-30)
  > 0.04 (age 1-12 months)
  > 0.05 (age 1-4 years)
  > 0.06 (age 5-10 years)
  > 0.1 (age >10 years)
Hepatic Presence of three or moreof the following
 INR
  >1.7 (day 1-4)
  >1.5 (day 5-29)
  >1.3 (>30 days)
 In absence of warfarin anticoagulation
 AST >100 U/l
 Serum albumin:
  <23 g/l (age <12 months)
  <30 g/l (age>12 months)
 Conjugated bilirubin >10 mmol/l
Haemostasis Presence of two or more of the following:
 Leucocytes <1×109/1
 Platelets <20×109/l
 INR
  >1.7 (age day 1-4)
  >1.5 (age day 5-29)
  >1.3 (>30 days)
 In absence of warfarin anticoagulation
 D-dimers >0.25
 APTT (sec)
  Premature neonates
   >80 (day 1)
   >75 (day 5)
   >65 (day 30)
   >50 (>day 180)
  Term infants
   >60 (day 1)
   >55 (day 30)
   >50 (>day 180)
 In absence of heparin anticoagulation
Brain Glascow motor score <4 (at any one point in the day in absence of sedation)
  • A-ado 2 = alveolar-arterial oxygen tension difference; APTT = activated partial thromboplastin time; AST = asparate aminotransferase; INR = international normalised ratio; Paco 2 = arterial oxygen tension.