RT Journal Article
SR Electronic
T1 Cardiopulmonary fitness in children with asthma versus healthy children
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 204
OP 210
DO 10.1136/archdischild-2021-323733
VO 108
IS 3
A1 Johan Moreau
A1 Floriane Socchi
A1 Marie Catherine Renoux
A1 Anne Requirand
A1 Hamouda Abassi
A1 Sophie Guillaumont
A1 Stefan Matecki
A1 Helena Huguet
A1 Martina Avesani
A1 Marie-Christine Picot
A1 Pascal Amedro
YR 2023
UL http://adc.bmj.com/content/108/3/204.abstract
AB Objectives To evaluate, with a cardiopulmonary exercise test (CPET), the cardiopulmonary fitness of children with asthma, in comparison to healthy controls, and to identify the clinical and CPET parameters associated with the maximum oxygen uptake (VO2max) in childhood asthma.Design This cross-sectional controlled study was carried out in CPET laboratories from two tertiary care paediatric centres. The predictors of VO2max were determined using a multivariable analysis.Results A total of 446 children (144 in the asthma group and 302 healthy subjects) underwent a complete CPET. Mean VO2max was significantly lower in children with asthma than in controls (38.6±8.6 vs 43.5±7.5 mL/kg/min; absolute difference (abs. diff.) of −4.9 mL/kg/min; 95% CI of (−6.5 to −3.3) mL/kg/min; p<0.01) and represented 94%±9% and 107%±17% of predicted values, respectively (abs. diff. −13%; 95% CI (−17 to −9)%; p<0.01). The proportion of children with an impaired VO2max was four times higher in the asthma group (24% vs 6%, p<0.01). Impaired ventilatory efficiency with increased VE/VCO2 slope and low breathing reserve (BR) were more marked in the asthma group. The proportion of children with a decreased ventilatory anaerobic threshold (VAT), indicative of physical deconditioning, was three times higher in the asthma group (31% vs 11%, p<0.01). Impaired VO2max was associated with female gender, high body mass index (BMI), FEV1, low VAT and high BR.Conclusion Cardiopulmonary fitness in children with asthma was moderately but significantly altered compared with healthy children. A decreased VO2max was associated with female gender, high BMI and the pulmonary function.Trial registration number NCT04650464.All data relevant to the study are included in the article or uploaded as supplementary information.