RT Journal Article
SR Electronic
T1 Prevalence of SARS-CoV-2 positivity in infants with bronchiolitis: a multicentre international study
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 840
OP 844
DO 10.1136/archdischild-2021-323559
VO 107
IS 9
A1 Giorgio Cozzi
A1 Luisa Cortellazzo Wiel
A1 Alessandro Amaddeo
A1 Antonio Gatto
A1 Manuela Giangreco
A1 Adi Klein-Kremer
A1 Samantha Bosis
A1 Davide Silvagni
A1 Carla Debbia
A1 Laura Nanni
A1 Sara Chiappa
A1 Marta Minute
A1 Ilaria Corsini
A1 Giuliana Morabito
A1 Anna Jolanda Gortan
A1 Marco Colombo
A1 Federico Marchetti
A1 Davide Garelli
A1 Arianna Piffer
A1 Fabio Cardinale
A1 Nitai Levy
A1 Antonietta Curatola
A1 Bojana Gojsina
A1 Suvradeep Basu
A1 Egidio Barbi
A1 Aleksandar Sovtic
A1 ,
YR 2022
UL http://adc.bmj.com/content/107/9/840.abstract
AB Background Bronchiolitis is the leading acute respiratory tract infection in infants during the winter season. Since the beginning of the SARS-CoV-2 pandemic, a reduction in the number of bronchiolitis diagnoses has been registered.Objective The present study aimed to describe the incidence and clinical features of bronchiolitis during the 2020–2021 winter season in a large cohort of children in Europe and Israel, and to clarify the role of SARS-CoV-2.Setting, patients, interventions We conducted a multicentre observational cross-sectional study in 23 paediatric emergency departments in Europe and Israel. Clinical and demographic data about all the cases of infants diagnosed with bronchiolitis from 1 October 2020 to 30 April 2021 were collected. For each enrolled patient, diagnostic tests, treatments and outcomes were reported.Main outcome measures The main outcome was the prevalence of SARS-CoV-2-positive bronchiolitis.Results Three hundred and fourteen infants received a diagnosis of bronchiolitis during the study period. Among 535 infants who tested positive for SARS-CoV-2, 16 (3%) had bronchiolitis. Median age, male sex predominance, weight, history of prematurity and presence of comorbidities did not differ between the SARS-CoV-2-positive and SARS-CoV-2-negative groups. Rhinovirus was the most common involved pathogen, while respiratory syncytial virus (RSV) was detected in one case. SARS-CoV-2 bronchiolitis had a mild clinical course, with one patient receiving oxygen supplementation and none requiring paediatric or neonatal intensive care unit admission.Conclusions During the SARS-CoV-2 pandemic, a marked decrease in the number of bronchiolitis diagnoses and the disappearance of the RSV winter epidemic were observed. SARS-CoV-2-related bronchiolitis was rare and mostly displayed a mild clinical course.Data are available on reasonable request.