TY - JOUR T1 - Are trough tobramycin concentrations taken from a central venous catheter accurate enough to safely use? JF - Archives of Disease in Childhood JO - Arch Dis Child SP - 512 LP - 514 DO - 10.1136/archdischild-2022-323836 VL - 107 IS - 5 AU - Hannah Tumelty AU - Geoff Shenton AU - Malcolm Brodlie Y1 - 2022/05/01 UR - http://adc.bmj.com/content/107/5/512.abstract N2 - A 15-year-old girl with cystic fibrosis (CF) and needle phobia has recently had a port-a-cath placed to facilitate regular intravenous antibiotic administration. She is admitted to the respiratory ward to receive ceftazidime and tobramycin to treat Pseudomonas aeruginosa. Local guidance requests a blood sample for trough tobramycin concentration to be taken peripherally prior to the second dose. This is due to concerns about the risk of falsely elevated concentrations if sampled from the same line used to give the drug. The patient is anxious and asks, “why can’t you just take it from my port like other blood tests?”In other departments, such as paediatric oncology, antibiotic concentrations are sampled from the same central line through which the drug is given, prompting us to question could we also spare our respiratory patients the trauma of a peripheral venepuncture to measure tobramycin trough concentrations?In children … ER -