TY - JOUR T1 - Highlights from this issue JF - Archives of Disease in Childhood JO - Arch Dis Child SP - i LP - i DO - 10.1136/archdischild-2021-323589 VL - 107 IS - 1 AU - Nick Brown Y1 - 2022/01/01 UR - http://adc.bmj.com/content/107/1/i.abstract N2 - The state of being ‘in vogue’ implies an ephemeral, transitory period where an idea, person, subject or even philosophy catches the broader eye and consciousness. The ‘entity’ enjoys a Warholian 15 min of fame before disappearing entirely or at least from view. That the internet can now capture these ‘15 min’ spells affords them greater long term accessibility, but does nothing for their active shelf lives, inevitably, short as a result of a societal concentration spans. Greater permanence is possible for subjects not in vogue, but of perpetual importance. These problems have eluded, evaded and defied us for decades, centuries, sometimes millennia, but are those where advances are ground-breaking, permanent and, well, exciting in their ‘unvoguishness’.Anyone who has witnessed a child succumbing inexorably to tuberculous meningitis will recognise the feeling of helplessness despite seemingly appropriate (isoniazid, rifampicin, pyrazinamide and ethionamide) treatment. This gives the pharmacokinetic paper in, the ever thought-provoking, Drug and Therapeutics section by Rovina Ruslami and colleagues in an Indonesian-Dutch collaboration, even more resonance. In several children CSF drug levels on standard doses were suboptimal … ER -