TY - JOUR T1 - Rise in children presenting with periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome during the COVID-19 pandemic JF - Archives of Disease in Childhood JO - Arch Dis Child SP - e49 LP - e49 DO - 10.1136/archdischild-2021-322792 VL - 106 IS - 12 AU - Khuen Foong Ng AU - Joseph Morgan AU - Thomas Cutts AU - Isabel Duncan AU - Marion Roderick AU - Athimalaipet Ramanan AU - Anu Goenka Y1 - 2021/12/01 UR - http://adc.bmj.com/content/106/12/e49.abstract N2 - Periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome is characterised by episodes of fever lasting a few days that classically exhibit clockwork periodicity. Since the initial description of PFAPA syndrome by Gary Marshall in 1987, it has been recognised that stomatitis, pharyngitis and adenitis are variably present.1 Its phenotype is consistent with an autoinflammatory condition of unknown genetic aetiology possibly involving an infectious/environmental trigger, given that a family history is present in approximately 27% of cases.2 The natural history is onset before 6 years old, followed by spontaneous resolution by 15 years. Treatment with colchicine can reduce the frequency of episodes and tonsillectomy is usually curative.3 The diagnosis of PFAPA syndrome is clinical but can be challenging because it predominantly affects young children who typically experience frequent febrile viral infections. We hypothesised that reduced transmission of viruses due to COVID-19 public health control measures … ER -