TY - JOUR T1 - Perinatal outcomes among births to women with infection during pregnancy JF - Archives of Disease in Childhood JO - Arch Dis Child SP - 946 LP - 953 DO - 10.1136/archdischild-2021-321865 VL - 106 IS - 10 AU - Adama Baguiya AU - Mercedes Bonet AU - José Guilherme Cecatti AU - Vanessa Brizuela AU - Ala Curteanu AU - Meile Minkauskiene AU - Kapila Jayaratne AU - Carolina Carvalho Ribeiro-do-Valle AU - Mihaela-Alexandra Budianu AU - João Paulo Souza AU - Séni Kouanda A2 - , Y1 - 2021/10/01 UR - http://adc.bmj.com/content/106/10/946.abstract N2 - Objective This study is part of the Global Maternal Sepsis Study (GLOSS). It aimed to estimate neonatal near-miss (NNM) and perinatal death frequency and maternal risk factors among births to women with infection during pregnancy in low-income and middle-income countries (LMIC).Design We conducted a 1-week inception hospital-based cohort study.Setting The study was carried out in 408 hospitals in 43 LMIC of all the WHO regions in 2017.Patients We included women with suspected or confirmed infection during pregnancy with at least 28 weeks of gestational age up to day-7 after birth. All babies born to those women were followed from birth until the seventh day after childbirth. Perinatal outcomes were considered at the end of the follow-up.Main outcome measures Perinatal outcomes were (i) babies alive without severe complication, (ii) NNM and (iii) perinatal death (stillbirth and early neonatal death).Results 1219 births were analysed. Among them, 25.9% (n=316) and 10.1% (n=123) were NNM and perinatal deaths, respectively. After adjustment, maternal pre-existing medical condition (adjusted odds ratios (aOR)=1.5; 95% CI 1.1 to 2.0) and maternal infection suspected or diagnosed during labour (aOR=1.9; 95% CI 1.2 to 3.2) were the independent risk factors of NNM. Maternal pre-existing medical condition (aOR=1.7; 95% CI 1.0 to 2.8), infection-related severe maternal outcome (aOR=3.8; 95% CI 2.0 to 7.1), mother’s infection suspected or diagnosed within 24 hours after childbirth (aOR=2.2; 95% CI 1.0 to 4.7) and vaginal birth (aOR=1.8; 95% CI 1.1 to 2.9) were independently associated with increased odds of perinatal death.Conclusions Overall, one-third of births were adverse perinatal outcomes. Pre-existing maternal medical conditions and severe infection-related maternal outcomes were the main risk factors of adverse perinatal outcomes.Data are available on reasonable request. Individual countries own GLOSS country-level data. The WHO owns the global data used for this analysis, and they are available on request from the WHO’s study coordinator in Geneva. ER -