TY - JOUR T1 - Hydrocortisone muco-adhesive buccal tablets continue to be used for the treatment of adrenal insufficiency in children in the UK JF - Archives of Disease in Childhood JO - Arch Dis Child SP - 826 LP - 826 DO - 10.1136/archdischild-2020-319865 VL - 106 IS - 8 AU - Meera Shaunak AU - Indraneel Banerjee AU - Justin Huw Davies Y1 - 2021/08/01 UR - http://adc.bmj.com/content/106/8/826.1.abstract N2 - Adrenal insufficiency (AI) is caused by inadequate cortisol production by the adrenal glands and is a life-threatening disorder in children and young people. It is important to ensure good adherence to hydrocortisone prescribed as cortisol replacement in AI. Several hydrocortisone preparations are available, with wide variation in prescribing practices.1 However, not all preparations are recommended for regular therapy of AI; recently, the Medicines and Healthcare products Regulatory Agency (MHRA) issued a safety alert recommending against the off-label use of hydrocortisone muco-adhesive buccal (buccal-HC) tablets, citing insufficient cortisol absorption and consequent risk of life-threatening adrenal crisis.2 Since the MHRA safety alert, the British … ER -