RT Journal Article
SR Electronic
T1 Post-COVID-19 paediatric inflammatory multisystem syndrome: association of ethnicity, key worker and socioeconomic status with risk and severity
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP archdischild-2020-320388
DO 10.1136/archdischild-2020-320388
A1 Jonathan Broad
A1 Julia Forman
A1 James Brighouse
A1 Adebola Sobande
A1 Alysha McIntosh
A1 Claire Watterson
A1 Elizabeth Boot
A1 Felicity Montgomery
A1 Iona Gilmour
A1 Joy Tan
A1 Mary Johanna Fogarty
A1 Xabier Gomez
A1 Ronny Cheung
A1 Jon Lillie
A1 Vinay Shivamurthy
A1 Jenny Handforth
A1 Owen Miller
A1 ,
YR 2021
UL http://adc.bmj.com/content/early/2021/03/09/archdischild-2020-320388.abstract
AB Objectives Patients from ethnic minority groups and key workers are over-represented among adults hospitalised or dying from COVID-19. In this population-based retrospective cohort, we describe the association of ethnicity, socioeconomic and family key worker status with incidence and severity of Paediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-CoV-2 (PIMS-TS).Setting Evelina London Children’s Hospital (ELCH), the tertiary paediatric hospital for the South Thames Retrieval Service (STRS) region.Participants 70 children with PIMS-TS admitted 14 February 2020–2 June 2020.Outcome measures Incidence and crude ORs are presented, comparing ethnicity and socioeconomic status of our cohort and the catchment population, using census data and Index of Multiple Deprivation (IMD). Regression is used to estimate the association of ethnicity and IMD with admission duration and requirement for intensive care, inotropes and ventilation.Results Incidence was significantly higher in children from black (25.0 cases per 100 000 population), Asian (6.4/100 000) and other (17.8/100 000) ethnic groups, compared with 1.6/100 000 in white ethnic groups (ORs 15.7, 4.0 and 11.2, respectively). Incidence was higher in the three most deprived quintiles compared with the least deprived quintile (eg, 8.1/100 000 in quintile 1 vs 1.6/100 000 in quintile 5, OR 5.2). Proportions of families with key workers (50%) exceeded catchment proportions. Admission length of stay was 38% longer in children from black ethnic groups than white (95% CI 4% to 82%; median 8 days vs 6 days). 9/10 children requiring ventilation were from black ethnic groups.Conclusions Children in ethnic minority groups, living in more deprived areas and in key worker families are over-represented. Children in black ethnic groups had longer admissions; ethnicity may be associated with ventilation requirement.This project was registered with the ELCH audit and service evaluation team, ref. no 11186.