RT Journal Article SR Electronic T1 Life-threatening hypersensitivity pneumonitis secondary to e-cigarettes JF Archives of Disease in Childhood JO Arch Dis Child FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health SP 1114 OP 1116 DO 10.1136/archdischild-2019-317889 VO 105 IS 11 A1 Nisha Nair A1 Matthew Hurley A1 Simon Gates A1 Patrick Davies A1 I-Ling Chen A1 Ian Todd A1 Lucy Fairclough A1 Andrew Bush A1 Jayesh Mahendra Bhatt YR 2020 UL http://adc.bmj.com/content/105/11/1114.abstract AB We report a case of hypersensitivity pneumonitis (HP) in a young person secondary to vaping. He presented with a putative diagnosis of asthma and required extracorporeal membrane oxygenationbecause of intractable respiratory failure. He developed a critical illness and steroid myopathy and required prolonged rehabilitation. Our patient fulfils diagnostic criteria for HP secondary to e-cigarettes with a positive exposure history, deterioration after skin prick testing, specific serum IgM antibodies against the implicated liquid raising the possibility that the relevant antigen was present in that liquid and radiological and histopathological features compatible with acute HP. There are two learning points. The first is always to consider a reaction to e-cigarettes in someone presenting with an atypical respiratory illness. The second is that we consider e-cigarettes as ‘much safer than tobacco’ at our peril.