RT Journal Article
SR Electronic
T1 Desmopressin oral lyophilisate in young children: new insights in pharmacokinetics and pharmacodynamics
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP archdischild-2019-318225
DO 10.1136/archdischild-2019-318225
A1 Lien Dossche
A1 Robin Michelet
A1 Pauline De Bruyne
A1 Charlotte Van Herzeele
A1 Elke Gasthuys
A1 Søren Rittig
A1 An Vermeulen
A1 Johan Vande Walle
YR 2020
UL http://adc.bmj.com/content/early/2020/07/31/archdischild-2019-318225.abstract
AB Objective To study the pharmacokinetic (PK)/pharmacodynamic (PD) characteristics of desmopressin (dDAVP) oral lyophilisate in children below the age of 8 years with special emphasis on age-related and size-related differences in bioavailability.Design Open label, non-randomised, interventional PK and PD trial.Setting Single-centre study.Patients Children (age: 6 months to 8 years) with nocturnal polyuria, including both children with uropathy or nephropathy (glomerular filtration rate >60 mL/min/1.73 m²) and children (age: 5–8 years) with severe monosymptomatic nocturnal enuresis, who were unresponsive to treatment with 400 µg of the dDAVP tablet for at least 1 month.Interventions After a water load, dDAVP was administered sublingually as a single dose of oral lyophilisate. Subsequently, blood and urine samples were collected until 7 hours post-administration.Main outcome measures Non-compartmental analysis of PK parameters was performed based on dDAVP concentrations in both plasma and urine. To evaluate the effect of dDAVP lyophilisate (PD parameters), the urinary concentration capacity (urine osmolality (mOsm/kg)) and antidiuretic effect (diuresis rate (mL/kg/h)) were calculated.Results The PK data support the need for size-dependent dosing in children. Body weight was shown to be a significant covariate for apparent clearance (CL/F) and apparent volume of distribution (Vd/F). A double absorption peak of dDAVP lyophilisate in the first 2 hours post-administration was demonstrated.Conclusions For the first time, a double absorption profile of dDAVP lyophilisate was found in children, questioning extrapolation of bioequivalence from adults towards children. Moreover, the need for size-adapted dosing regimens of dDAVP lyophilisate in young children is indicated.Trial registration number NTC02584231.