TY - JOUR T1 - Hypertonic saline in bronchiolitis: an updated meta-analysis JF - Archives of Disease in Childhood JO - Arch Dis Child DO - 10.1136/archdischild-2020-319048 SP - archdischild-2020-319048 AU - Paula Heikkilä AU - Matti Korppi Y1 - 2020/03/25 UR - http://adc.bmj.com/content/early/2020/03/25/archdischild-2020-319048.abstract N2 - Hypertonic saline (HS) inhalations in infants hospitalised for bronchiolitis are still under discussion, although 20 randomised controlled trials (RCTs) have evaluated the effectiveness.1–3 Two RCTs, one from Japan2 and another from Switzerland,3 were published until 31 January 2020 after our cumulative meta-analysis,1 which covered data until 30 June 2017.Morikawa et al randomised 63 Japanese children hospitalised for moderately severe bronchiolitis caused by respiratory syncytial virus at <12 months of age to receive 3% HS and 65 to receive normal saline (NS) inhalations four times a day.2 Saline inhalations were routinely administered combined with nebulised salbutamol. Nine (14.3%) and 7 (10.9%) children, respectively, received additional inhalations. Jaquet-Pilloud et al … ER -