RT Journal Article
SR Electronic
T1 Compatibility of pentoxifylline and parenteral medications
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP archdischild-2019-317912
DO 10.1136/archdischild-2019-317912
A1 Anna L Campbell
A1 Michael Petrovski
A1 SMDK Ganga Senarathna
A1 Nabeelah Mukadam
A1 Tobias Strunk
A1 Kevin T Batty
YR 2019
UL http://adc.bmj.com/content/early/2019/12/22/archdischild-2019-317912.abstract
AB Objective To investigate the physical and chemical compatibility of pentoxifylline (PTX) with a range of parenteral medications used in neonatal intensive care.Design PTX and drug solutions were combined in glass vials, inspected for physical incompatibility and evaluated on the basis of PTX concentrations for chemical compatibility.Results No precipitation, colour change or turbidity was observed in any of the test mixtures. The PTX concentration was approximately 5.5% lower when combined with undiluted calcium gluconate injection (100 mg/mL). The PTX concentration ratios for all other combinations, including diluted calcium gluconate injection (50 mg/mL), were in the range of 99.5%–102%.Conclusion In simulated Y-site conditions, PTX was found to be compatible with 15 parenteral medications and six total parenteral nutrition solutions. Based on PTX concentration tests, it would be prudent to avoid mixing PTX with undiluted calcium gluconate injection.