PT  - JOURNAL ARTICLE
AU  - Anna L Campbell
AU  - Michael Petrovski
AU  - SMDK Ganga Senarathna
AU  - Nabeelah Mukadam
AU  - Tobias Strunk
AU  - Kevin T Batty
TI  - Compatibility of pentoxifylline and parenteral medications
AID  - 10.1136/archdischild-2019-317912
DP  - 2019 Dec 23
TA  - Archives of Disease in Childhood
PG  - archdischild-2019-317912
4099  - http://adc.bmj.com/content/early/2019/12/22/archdischild-2019-317912.short
4100  - http://adc.bmj.com/content/early/2019/12/22/archdischild-2019-317912.full
AB  - Objective To investigate the physical and chemical compatibility of pentoxifylline (PTX) with a range of parenteral medications used in neonatal intensive care.Design PTX and drug solutions were combined in glass vials, inspected for physical incompatibility and evaluated on the basis of PTX concentrations for chemical compatibility.Results No precipitation, colour change or turbidity was observed in any of the test mixtures. The PTX concentration was approximately 5.5% lower when combined with undiluted calcium gluconate injection (100 mg/mL). The PTX concentration ratios for all other combinations, including diluted calcium gluconate injection (50 mg/mL), were in the range of 99.5%–102%.Conclusion In simulated Y-site conditions, PTX was found to be compatible with 15 parenteral medications and six total parenteral nutrition solutions. Based on PTX concentration tests, it would be prudent to avoid mixing PTX with undiluted calcium gluconate injection.