RT Journal Article
SR Electronic
T1 Epidemiology of congenital cerebral anomalies in Europe: a multicentre, population-based EUROCAT study
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 1181
OP 1187
DO 10.1136/archdischild-2018-316733
VO 104
IS 12
A1 Joan K Morris
A1 Diana G Wellesley
A1 Ingeborg Barisic
A1 Marie-Claude Addor
A1 Jorieke E H Bergman
A1 Paula Braz
A1 Clara Cavero-Carbonell
A1 Elizabeth S Draper
A1 Miriam Gatt
A1 Martin Haeusler
A1 Kari Klungsoyr
A1 Jennifer J Kurinczuk
A1 Natalie Lelong
A1 Karen Luyt
A1 Catherine Lynch
A1 Mary T O’Mahony
A1 Olatz Mokoroa
A1 Vera Nelen
A1 Amanda J Neville
A1 Anna Pierini
A1 Hanitra Randrianaivo
A1 Judith Rankin
A1 Anke Rissmann
A1 Florence Rouget
A1 Bruno Schaub
A1 David F Tucker
A1 Christine Verellen-Dumoulin
A1 Awi Wiesel
A1 Natalia Zymak-Zakutnia
A1 Monica Lanzoni
A1 Ester Garne
YR 2019
UL http://adc.bmj.com/content/104/12/1181.abstract
AB Objectives To describe the epidemiology and geographical differences in prevalence of congenital cerebral anomalies in Europe.Design and setting Congenital cerebral anomalies (International Classification of Diseases, 10th Revision code Q04) recorded in 29 population-based EUROCAT registries conducting surveillance of 1.7 million births per annum (29% of all European births).Participants All birth outcomes (live births, fetal deaths from 20 weeks gestation and terminations of pregnancy after prenatal diagnosis of a fetal anomaly (TOPFA)) from 2005 to 2014.Main outcome measures Prevalence, proportion of associated non-cerebral anomalies, prenatal detection rate.Results 4927 cases with congenital cerebral anomalies were identified; a prevalence (adjusted for under-reporting) of 9.8 (95% CI: 8.5 to 11.2) per 10 000 births. There was a sixfold difference in prevalence across the registries. Registries with higher proportions of prenatal diagnoses had higher prevalence. Overall, 55% of all cases were liveborn, 3% were fetal deaths and 41% resulted in TOPFA. Forty-eight per cent of all cases were an isolated cerebral anomaly, 25% had associated non-cerebral anomalies and 27% were chromosomal or part of a syndrome (genetic or teratogenic). The prevalence excluding genetic or chromosomal conditions increased by 2.4% per annum (95% CI: 1.3% to 3.5%), with the increases occurring only for congenital malformations of the corpus callosum (3.0% per annum) and ‘other reduction deformities of the brain’ (2.8% per annum).Conclusions Only half of the cases were isolated cerebral anomalies. Improved prenatal and postnatal diagnosis may account for the increase in prevalence of congenital cerebral anomalies from 2005 to 2014. However, major differences in prevalence remain between regions.