PT  - JOURNAL ARTICLE
AU  - Francesco Di Mattia
AU  - Robyn Fary
AU  - Kevin J Murray
AU  - Erin Howie
AU  - Anne Smith
AU  - Susan Morris
TI  - Two subtypes of symptomatic joint hypermobility: a descriptive study using latent class analysis
AID  - 10.1136/archdischild-2017-314149
DP  - 2019 Nov 01
TA  - Archives of Disease in Childhood
PG  - 1099--1101
VI  - 104
IP  - 11
4099  - http://adc.bmj.com/content/104/11/1099.short
4100  - http://adc.bmj.com/content/104/11/1099.full
SO  - Arch Dis Child2019 Nov 01; 104
AB  - Objective To investigate a cohort of children with symptomatic joint hypermobility.Methods Case notes for 318 children with joint hypermobility attending a rheumatology clinic were reviewed for clinical presentation, medical history, psychosocial factors and physical examination findings. Seven key variables were extracted and used as indicator variables in a latent class analysis to estimate the presence and number of subgroups of children with symptomatic joint hypermobility.Results Two subgroups with differing clinical presentations were identified accounting for age and gender: an ‘athletic-persistent’ class (62%) characterised by higher probabilities for recurrent and chronic musculoskeletal pain, and less severe hypermobility; and a ‘systemic-profound’ class (38%) characterised by generalised hypermobility, recurrent musculoskeletal pain, gastro-oesophageal reflux and motor delay.Conclusion Findings suggest the presence of two distinct presentations of children with hypermobility. This finding may be important for clinical decision-making and management of this group of children.