RT Journal Article
SR Electronic
T1 Parents’ prioritised outcomes for trials investigating treatments for paediatric severe infection: a qualitative synthesis
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP archdischild-2019-316807
DO 10.1136/archdischild-2019-316807
A1 Kerry Woolfall
A1 Caitlin O’Hara
A1 Elizabeth Deja
A1 Ruth Canter
A1 Imran Khan
A1 Paul Mouncey
A1 Anjali Carter
A1 Nicola Jones
A1 Jason Watkins
A1 Mark David Lyttle
A1 Lyvonne Tume
A1 Rachel Agbeko
A1 Shane M Tibby
A1 John Pappachan
A1 Kent Thorburn
A1 Kathryn M Rowan
A1 Mark John Peters
A1 David Inwald
A1 ,
YR 2019
UL http://adc.bmj.com/content/early/2019/06/07/archdischild-2019-316807.abstract
AB Objective To identify parents’ prioritised outcomes by combining qualitative findings from two trial feasibility studies of interventions for paediatric suspected severe infection.Design Qualitative synthesis combining parent interview data from the Fluids in Shock (FiSh) and Fever feasibility studies. Parents had experience of their child being admitted to a UK emergency department or intensive care unit with a suspected infection.Participants n=: 85 parents. FiSh study: n=41 parents, 37 mothers, 4 fathers, 7 were bereaved. Fever study: n=44 parents, 33 mothers, 11 fathers, 7 were bereaved.Results In addition to survival, parents prioritised short-term outcomes including: organ and physiological functioning (eg, heart rate, breathing rate and temperature); their child looking and/or behaving more like their normal self; and length of time on treatments or mechanical support. Longer term prioritised outcomes included effects of illness on child health and development. We found that parents’ prioritisation of outcomes was influenced by their experience of their child’s illness, survival and the point at which they are asked about outcomes of importance in the course of their child’s illness.Conclusions Findings provide insight into parent prioritised outcomes to inform the design of future trials investigating treatments for paediatric suspected or proven severe infection as well as core outcome set development work.