@article {Woolfallarchdischild-2019-316807, author = {Kerry Woolfall and Caitlin O{\textquoteright}Hara and Elizabeth Deja and Ruth Canter and Imran Khan and Paul Mouncey and Anjali Carter and Nicola Jones and Jason Watkins and Mark David Lyttle and Lyvonne Tume and Rachel Agbeko and Shane M Tibby and John Pappachan and Kent Thorburn and Kathryn M Rowan and Mark John Peters and David Inwald}, editor = {,}, title = {Parents{\textquoteright} prioritised outcomes for trials investigating treatments for paediatric severe infection: a qualitative synthesis}, elocation-id = {archdischild-2019-316807}, year = {2019}, doi = {10.1136/archdischild-2019-316807}, publisher = {BMJ Publishing Group Ltd}, abstract = {Objective To identify parents{\textquoteright} prioritised outcomes by combining qualitative findings from two trial feasibility studies of interventions for paediatric suspected severe infection.Design Qualitative synthesis combining parent interview data from the Fluids in Shock (FiSh) and Fever feasibility studies. Parents had experience of their child being admitted to a UK emergency department or intensive care unit with a suspected infection.Participants n=: 85 parents. FiSh study: n=41 parents, 37 mothers, 4 fathers, 7 were bereaved. Fever study: n=44 parents, 33 mothers, 11 fathers, 7 were bereaved.Results In addition to survival, parents prioritised short-term outcomes including: organ and physiological functioning (eg, heart rate, breathing rate and temperature); their child looking and/or behaving more like their normal self; and length of time on treatments or mechanical support. Longer term prioritised outcomes included effects of illness on child health and development. We found that parents{\textquoteright} prioritisation of outcomes was influenced by their experience of their child{\textquoteright}s illness, survival and the point at which they are asked about outcomes of importance in the course of their child{\textquoteright}s illness.Conclusions Findings provide insight into parent prioritised outcomes to inform the design of future trials investigating treatments for paediatric suspected or proven severe infection as well as core outcome set development work.}, issn = {0003-9888}, URL = {https://adc.bmj.com/content/early/2019/06/07/archdischild-2019-316807}, eprint = {https://adc.bmj.com/content/early/2019/06/07/archdischild-2019-316807.full.pdf}, journal = {Archives of Disease in Childhood} }