TY - JOUR T1 - Toxicity of long-term use of proton pump inhibitors in children JF - Archives of Disease in Childhood JO - Arch Dis Child SP - 78 LP - 82 DO - 10.1136/archdischild-2017-314026 VL - 103 IS - 1 AU - Pauline De Bruyne AU - Shinya Ito Y1 - 2018/01/01 UR - http://adc.bmj.com/content/103/1/78.abstract N2 - Proton pump inhibitor (PPI) use is becoming increasingly common. Although the toxicity profiles of PPIs are not well understood particularly in children, PPIs have been associated with increased risks of gastrointestinal and respiratory tract infection, vitamin B12 deficiency, hypomagnesaemia, bone fractures, and rebound hyperacidity after discontinuation. Prescribers should take into account that PPI uses pose toxicity risks, which remain to be fully characterised in infants and children. ER -