RT Journal Article
SR Electronic
T1 Toxicity of long-term use of proton pump inhibitors in children
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 78
OP 82
DO 10.1136/archdischild-2017-314026
VO 103
IS 1
A1 Pauline De Bruyne
A1 Shinya Ito
YR 2018
UL http://adc.bmj.com/content/103/1/78.abstract
AB Proton pump inhibitor (PPI) use is becoming increasingly common. Although the toxicity profiles of PPIs are not well understood particularly in children, PPIs have been associated with increased risks of gastrointestinal and respiratory tract infection, vitamin B12 deficiency, hypomagnesaemia, bone fractures, and rebound hyperacidity after discontinuation. Prescribers should take into account that PPI uses pose toxicity risks, which remain to be fully characterised in infants and children.