TY - JOUR T1 - Are neutrophils the culprit in CF lung damage? JF - Archives of Disease in Childhood JO - Arch Dis Child DO - 10.1136/archdischild-2017-314246 SP - archdischild-2017-314246 AU - Robert Scott-Jupp Y1 - 2017/10/22 UR - http://adc.bmj.com/content/early/2017/10/21/archdischild-2017-314246.abstract N2 - The progressive deterioration in lung function seen in cystic fibrosis (CF) has always been thought to be due to the primary effects of the gene mutation on respiratory mucosal secretions, compounded by bacterial infections. Although we knew that inflammation per se plays a part, exuberant inflammatory processes were thought to be a result of chronic infection rather than a primary effect of the mutation on inflammatory cells: until now. Researchers from Edinburgh conducted a series of experiments that implicate neutrophils, and more specifically neutrophil extracellular traps (NETs), … ER -