RT Journal Article
SR Electronic
T1 Hormone supplementation for pubertal induction in girls
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 975
OP 980
DO 10.1136/archdischild-2016-311372
VO 102
IS 10
A1 Debbie Matthews
A1 Louise Bath
A1 Wolfgang Högler
A1 Avril Mason
A1 Arlene Smyth
A1 Mars Skae
YR 2017
UL http://adc.bmj.com/content/102/10/975.abstract
AB Pubertal induction in girls with ovarian insufficiency aims to mimic normal puberty, a highly complex process. Here we amalgamate the sparse global evidence and propose three options for pubertal induction regimens including oral ethinyloestradiol, and oral and transdermal 17β-oestradiol. The introduction of progestogens is discussed and the transition to hormone supplementation for adult women. The merits and disadvantages of the different options are detailed. The available evidence indicates that transdermal 17β-oestradiol has the most favourable efficacy, safety and cost profile but randomised controlled trials are urgently required to determine which regimen provides the best clinical outcomes.