TY - JOUR T1 - Niacin, NAD and malformations JF - Archives of Disease in Childhood JO - Arch Dis Child DO - 10.1136/archdischild-2017-313941 SP - archdischild-2017-313941 AU - Robert Scott-Jupp Y1 - 2017/09/07 UR - http://adc.bmj.com/content/early/2017/09/07/archdischild-2017-313941.abstract N2 - It’s rare for a single paper to claim to have not only discovered a new mechanism for disease but also a means of preventing it. A paper from Sydney, Australia, which at first sight appears somewhat obscure and theoretical, does just that (Shi H et al. NEJM 2017. doi: 10.1056/NEJMoa1616361). It combines genetic studies on four families with mouse model experiments, to come up with a hypothesis that many congenital malformations are linked to deficiency of Nicotinamide Adenine Dinucleotide (NAD) in pregnancy. The families, 3 of which were consanguineous, all … ER -