TY - JOUR T1 - Sweat chloride and immunoreactive trypsinogen in infants carrying two <em>CFTR</em> mutations and not affected by cystic fibrosis JF - Archives of Disease in Childhood JO - Arch Dis Child SP - 644 LP - 646 DO - 10.1136/archdischild-2015-309348 VL - 102 IS - 7 AU - Carlo Castellani AU - Gloria Tridello AU - Anna Tamanini AU - Baroukh M Assael Y1 - 2017/07/01 UR - http://adc.bmj.com/content/102/7/644.abstract N2 - Newborns with raised immunotrypsinogen levels who have non-pathological sweat chloride values and carry two cystic fibrosis transmembrane regulator (CFTR) mutations of which at least one is not acknowledged to be cystic fibrosis (CF)-causing are at risk of developing clinical manifestations consistent with CFTR-related disorders or even CF. It is not known whether newborns with similar genotypes and normal immunoreactive trypsinogen (IRT) may share the same risk. This study found that newborns with these characteristics and normal IRT have lower sweat chloride values than those with raised IRT (p=0.007). ER -