TY - JOUR T1 - Adverse drug reactions of systemic antihistamines in children in the Netherlands JF - Archives of Disease in Childhood JO - Arch Dis Child SP - 968 LP - 970 DO - 10.1136/archdischild-2015-310315 VL - 101 IS - 10 AU - Tjalling W de Vries AU - Florence van Hunsel Y1 - 2016/10/01 UR - http://adc.bmj.com/content/101/10/968.abstract N2 - Background Antihistamines are used for the treatment of allergic rhinitis, allergic conjunctivitis, chronic spontaneous urticaria and atopic eczema.Objective To study the reports of adverse drug reactions (ADRs) in children using antihistamines to provide prescribers with an overview of the possible toxicity.Design We studied ADRs in children reported to the Netherlands Pharmacovigilance Centre Lareb in the years 1991–2014, assessed the Naranjo score and, when possible, computed the reporting OR.Results Serious ADRs included one death (malignant neuroleptic syndrome), cardiac arrhythmia (one case) and convulsions (three cases). Skin eruptions, headache and somnolence were the most frequently reported ADRs. Aggression and agitation were also reported.Conclusions Toxicity can occur with second-generation antihistamines. The main toxicity relates to skin eruptions and central nervous system problems. ER -