RT Journal Article
SR Electronic
T1 C3, factor B, alpha-1-antitrypsin in neonatal septicaemia with sclerema.
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 782
OP 788
DO 10.1136/adc.55.10.782
VO 55
IS 10
A1 Pelet, B
YR 1980
UL http://adc.bmj.com/content/55/10/782.abstract
AB C3, factor B, and alpha-1-antitrypsin were determined in newborn infants with septicaemia and sclerema, associated with suspected infections, ABO or Rh incompatibility, and hyperbilirubinaemia of unknown origin, during and after treatment with exchange transfusion. Activation products from C3 and factor B, the clearance of the transfused C3, and its synthesis by the recipient were determined also. Infected newborn infants had low levels of C3 and factor B, but a normal amount of alpha-1-antitrypsin. Exchange transfusion lowered the level of alpha-1-antitrypsin and briefly corrected the low level of C3 and factor B. Activation products were formed only exceptionally. As synthesis of C3 is very active, a defective activation of complement pathway linked to an abnormal distribution in extravascular pool is postulated.