TY - JOUR T1 - QUESTION 2: Vaccinating preterm infants in resource-poor settings: what is the incidence of apnoea, bradycardia and need for respiratory support? JF - Archives of Disease in Childhood JO - Arch Dis Child SP - 290 LP - 293 DO - 10.1136/archdischild-2015-310273 VL - 101 IS - 3 AU - Andrew James McArdle AU - Guy Mugisha AU - Dieudonne Birahinduka Y1 - 2016/03/01 UR - http://adc.bmj.com/content/101/3/290.abstract N2 - A 27-week gestation infant is approaching 2 months of age in a resource-poor hospital with no continuous monitoring or facilities for intubation. WHO guidance advocates vaccinating at 2 months, but you wonder about the possible risks of apnoea and bradycardia.In hospitalised premature infants (population) what is the incidence of apnoea, bradycardia and need for respiratory support (outcome) following routine vaccination (intervention).A PubMED search for ((‘Infant, Premature’ [Mesh] OR prematur* OR preterm) AND (‘Immunization’ [Mesh] OR ‘Vaccination’ [Mesh] OR Immunisation OR Immunization OR vaccination)) AND (‘Apnea’ [Mesh] OR apnoea OR apnea OR ‘Drug-Related Side Effects and Adverse Reactions’ [Mesh] OR adverse) found 312 articles (13 January 2016). A similar search of EMBASE found 428 articles.Thirty-four articles provided primary evidence related to adverse events following vaccination in preterm infants, with two obtained through hand-searching references of included studies. Four considered non-routine vaccinations or components, 13 were retrospective and two case series. Of the … ER -