PT  - JOURNAL ARTICLE
AU  - Gallagher, P
AU  - Murphy, N
AU  - Foran, A
TI  - INDICATIONS AND TIMING OF THYROID FUNCTION TESTS IN NEWBORNS
DP  - 2008 Nov 01
TA  - Archives of Disease in Childhood
PG  - ps504--ps504
VI  - 93
IP  - Suppl 2
4099  - http://adc.bmj.com/content/93/Suppl_2/ps504.short
4100  - http://adc.bmj.com/content/93/Suppl_2/ps504.full
SO  - Arch Dis Child2008 Nov 01; 93
AB  - Background Thyroid disorders affect approximately 1 per 3000 term infants. The majority are congenital hypothyroidism picked up by newborn screening (Guthrie). International guidelines advise checking TFTs in infants born to mothers if there is an autoimmune basis to the maternal thyroid disease or unknown cause. Testing should be deferred until 72 hours after delivery.Aims Audit TFTs performed on neonates in the Rotunda.Assess if the test was: indicated, done at the right time and an adequate sample.Aims Methods Retrospective review Jul–Dec 2007.Internal laboratory computer system.Chart review.Methods Results 57 infants had TFTs Jul–Dec ’07.15/89 samples (17%) were insufficient.5 with abnormal results: 4 detected by Guthrie and 1 presented with hypoglycaemia.17 infants had TFTs as a result of maternal thyroid disease. Of these: 11/17 were taken for the wrong reason or at the wrong time. 4 too late (>day 14) and 4 too early. 3/17 had TFTs performed unnecessarily as the mothers had previous surgery for benign thyroid lesions. None of these samples yielded positive results.Results Conclusion The Guthrie remains the gold standard screen for identifying infants with thyroid disease.This audit highlights the need for a guideline indicating appropriate indications and timing of TFTs for infants born to mothers with thyroid disease.In high-risk mothers with known antibodies or no known cause for their thyroid disease then samples must be correctly timed, to avoid repeated phlebotomy and missing potentially life-threatening thyrotoxicosis.Conclusion