PT - JOURNAL ARTICLE
AU - Huidekoper, Hidde H
AU - Ackermans, Mariëtte T
AU - Ruiter, An F C
AU - Sauerwein, Hans P
AU - Wijburg, Frits A
TI - Endogenous glucose production from infancy to adulthood: a non-linear regression model
AID - 10.1136/archdischild-2013-305718
DP - 2014 Dec 01
TA - Archives of Disease in Childhood
PG - 1098--1102
VI - 99
IP - 12
4099 - http://adc.bmj.com/content/99/12/1098.short
4100 - http://adc.bmj.com/content/99/12/1098.full
SO - Arch Dis Child2014 Dec 01; 99
AB - Objective To construct a regression model for endogenous glucose production (EGP) as a function of age, and compare this with glucose supplementation using commonly used dextrose-based saline solutions at fluid maintenance rate in children. Design A model was constructed based on EGP data, as quantified by [6,6-2H2] glucose dilution after fasting overnight during normoglycaemia, in 40 healthy subjects aged 2.5–54.3 years old. The data were analysed using non-linear regression modelling with a 1-phase exponential decay curve fit. This model was compared to the amount of glucose provided with 2.5% or 5% dextrose-based saline solutions infused at fluid maintenance rate. Results Non-linear regression analysis of the EGP data yielded the following regression model: EGP (mg/kg/min) = 6.50 × 2.72–0.145 × age (y)+1.93. Glucose supplementation at fluid maintenance rate with a 5% dextrose-based saline solution ranged from 46% at age 1 year to 55% at age 18 years of the glucose required to preclude the need for EGP. With a 2.5% dextrose-based solution, these percentages are 23% at age 1 year to 27% at age 18 years. Conclusions we present an accurate non-linear regression model for EGP as a function of age. With standard dextrose-based saline solutions infused at fluid maintenance rate, only approximately 50% or less of EGP is provided. With prolonged infusion of these solutions, the deficit between exogenous glucose supplementation and EGP may induce a catabolic state and may ultimately lead to hypoglycaemia, especially in younger children.