RT Journal Article SR Electronic T1 Recent advances in the management of cystic fibrosis JF Archives of Disease in Childhood JO Arch Dis Child FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health SP 1033 OP 1036 DO 10.1136/archdischild-2013-304400 VO 99 IS 11 A1 Jane C Davies A1 Anne-Marie Ebdon A1 Christopher Orchard YR 2014 UL http://adc.bmj.com/content/99/11/1033.abstract AB Cystic fibrosis is a disease that still causes a reduced life expectancy. The treatment burden remains high for affected individuals with often a combination of multiple oral and inhaled medications, as well as physiotherapy, required on a daily basis. In this article, we look at an overview of the pathogenesis, how this might lead to treatment options and look at some of the available new therapies, all in the aim of increasing life expectancy and reducing treatment burden.