TY - JOUR T1 - Interferon-γ release assays for the diagnosis of tuberculosis in children JF - Archives of Disease in Childhood JO - Arch Dis Child SP - 239 LP - 240 DO - 10.1136/archdischild-2012-302798 VL - 98 IS - 3 AU - Marc Tebruegge AU - Tom G Connell AU - Nicole Ritz AU - Nigel Curtis Y1 - 2013/03/01 UR - http://adc.bmj.com/content/98/3/239.1.abstract N2 - We read with interest the recent publication by Méndez-Echevarría et al which compared the performance of tuberculin skin tests (TST) with a commercial interferon-γ release assay (IGRA), the QuantiFERON-TB Gold In-Tube assay, for the diagnosis of latent tuberculosis infection (LTBI) and active TB disease (TBD) in children.1 However, we believe several aspects require clarification for readers. Consistent with previous studies evaluating TST and IGRA in children, a significant proportion (4.4%) of participants had indeterminate IGRA results and an even higher proportion (8.9%) had discordant results, which were predominately (38/41; 92.7%) TST+/IGRA−.2 Interestingly, almost all (67/68; 98.5%) children with TBD had concordantly positive … ER -