PT  - JOURNAL ARTICLE
AU  - Octavia, MBI
AU  - Neamtu, BM
AU  - Leonida, NM
AU  - Rodica, M
AU  - Rodica, C
AU  - Alina, Z
AU  - Ionela, M
AU  - Melania, M
AU  - Cristian, N
AU  - Radu, B
AU  - Ariela, O
TI  - 1716 Effects on Growth of Inhaled Corticosteroids in Asthmatic Children
AID  - 10.1136/archdischild-2012-302724.1716
DP  - 2012 Oct 01
TA  - Archives of Disease in Childhood
PG  - A485--A485
VI  - 97
IP  - Suppl 2
4099  - http://adc.bmj.com/content/97/Suppl_2/A485.2.short
4100  - http://adc.bmj.com/content/97/Suppl_2/A485.2.full
SO  - Arch Dis Child2012 Oct 01; 97
AB  - Background Corticosteroids may inhibit growth hormone (GH) axis, reducing GH release, decreasing tissue expression of growth factors, inhibiting IGF-1 bioactivity, osteoblast activity, promoting bone resorption. Objectives Evaluating adverse effects of inhaled corticosteroids used in asthmatic children on the following biological parameters: GH (two measurements), IGF-1(insulin growth factor-1), FAS (alkaline phosphatase), correlated with the presence or absence of atopy (immunoglobulin E levels). Methods The prospective study included 74 asthmatic children, treated with inhaled corticosteroids aged between 5 and 13 years of age, divided into subgroups. Each type of inhaled glucocorticoid fluticasone, budesonide, mometasone furoate (single or in combination with long-acting bronchodilators) has been analysed for each patient. T-test, Mann-Whitney, Chi-square, binomial tests were used to ascertain the relations between average dose, the duration of treatment and the biological parameters mentioned . Results There were found statistically significant differences (p<0.05) in: patients treated with Seretide 25/50 between the number of patients with GH values < 1ng/ml and number of patients with GH > 1ng/ml (second measurement of GH).patients treated with Symbicort 4.5/80, between the number of patients with GH values < 1ng/ml and number of patients with GH > 1ng/ml (first measurement of GH).patients treated with Seretide 50/100 for the following parameters: GH (both determinations), IgE and FAS. Conclusions Systemic effects of fluticasone propionate and budesonide formoterol in small and medium doses were noted in the association with long-acting bronchodilators and were more extensive accordingly to the duration of treatment.