PT  - JOURNAL ARTICLE
AU  - Stephanie Richards
AU  - George Chalkiadis
AU  - Raman Lakshman
AU  - Jim P Buttery
AU  - Nigel W Crawford
TI  - Complex regional pain syndrome following immunisation
AID  - 10.1136/archdischild-2011-301307
DP  - 2012 Oct 01
TA  - Archives of Disease in Childhood
PG  - 913--915
VI  - 97
IP  - 10
4099  - http://adc.bmj.com/content/97/10/913.short
4100  - http://adc.bmj.com/content/97/10/913.full
SO  - Arch Dis Child2012 Oct 01; 97
AB  - Complex regional pain syndrome type 1 (CRPS-1) is a clinical syndrome that affects one or more extremities and is characterised by persistent pain disproportionate to any inciting event, and at least one sign of autonomic dysfunction in the affected limb(s). The pathogenesis of this syndrome is poorly understood, but its onset is often precipitated by a physical injury, such as minor trauma, fracture, infection or a surgical procedure. In the literature, there are reports of CRPS-1 following immunisation with rubella and hepatitis B vaccines. Here we present a case series of CRPS-1 following immunisation in adolescents, with either diphtheria-tetanus-acellular pertussis (1 case), or human papillomavirus vaccines (4 cases). Enhanced awareness of this syndrome and its potential to occur following immunisation in the paediatric population is vital to the prompt and effective management of this condition.