PT  - JOURNAL ARTICLE
AU  - Pichler, Judith
AU  - Horn, Venetia
AU  - Macdonald, Sarah
AU  - Hill, Susan
TI  - Intestinal failure-associated liver disease in hospitalised children
AID  - 10.1136/archdischild-2011-300274
DP  - 2012 Mar 01
TA  - Archives of Disease in Childhood
PG  - 211--214
VI  - 97
IP  - 3
4099  - http://adc.bmj.com/content/97/3/211.short
4100  - http://adc.bmj.com/content/97/3/211.full
SO  - Arch Dis Child2012 Mar 01; 97
AB  - Objective and aim Liver disease is a potentially life-threatening complication of intravenous/parenteral nutrition (PN). Our aim was to determine the incidence, aetiology and outcome of intestinal failure-associated liver disease (IFALD) in hospitalised children treated with long-term PN (>27 days). Methods Over 4 years all long-term intestinal failure (IF) patients were reviewed for the possible predisposing factors of age, diagnosis, PN lipid, sepsis, length of PN treatment and length of hospitalisation. Outcome measures were IFALD incidence, severity and prognosis. Results Of 60/279 (22%) children aged 0–18 years who developed IFALD, 13 (5%) progressed to type 3/end stage disease. IFALD was associated with younger age (p=0.03), longer treatment (p<0.001), longer hospitalisation (p=0.01), surgical diagnosis (p=0.005) and prematurity (p=0.03). IFALD was not associated with sepsis. Intestinal surgery was associated with IFALD independently of age (p=0.03). Survival was 86%, with three deaths attributed to IFALD (1% of all cases), all of which were surgical. Conclusion IFALD incidence was lower than previously reported in paediatric patients, with surgical neonates at greatest risk.