PT  - JOURNAL ARTICLE
AU  - Michael Absoud
AU  - Carole Cummins
AU  - Nivedita Desai
AU  - Artemis Gika
AU  - Niamh McSweeney
AU  - Pinki Munot
AU  - Cheryl Hemingway
AU  - Ming Lim
AU  - Ken K Nischal
AU  - Evangeline Wassmer
TI  - Childhood optic neuritis clinical features and outcome
AID  - 10.1136/adc.2009.175422
DP  - 2011 Sep 01
TA  - Archives of Disease in Childhood
PG  - 860--862
VI  - 96
IP  - 9
4099  - http://adc.bmj.com/content/96/9/860.short
4100  - http://adc.bmj.com/content/96/9/860.full
SO  - Arch Dis Child2011 Sep 01; 96
AB  - Aim To describe clinical features and outcome of a series of children with first-episode optic neuritis investigated in three paediatric neurology centres. Methods Databases were searched to identify children (<16 years) with optic neuritis and life table analysis was used. Results 44 children (female/male ratio 1.8) median age 10.9 years were followed up for median 1 year. Optic neuritis was unilateral in 43%. Maximal visual deficit was severe (<6/60) in 77%, with full recovery in 70%. Cumulative probability of developing MS (11/44) or NMO (3/44) at 2 years was 0.45. Relapsing optic neuritis was a strong predictor for development of MS or NMO. A positive MRI (>1 brain T2 hyperintense lesion) was a strong predictor for development of MS. Discussion Childhood optic neuritis is associated with severe visual deficit with good recovery. An initial abnormal MRI brain scan or relapsing optic neuritis should alert the clinician to MS or NMO diagnosis.