RT Journal Article
SR Electronic
T1 Neonatal total IgE and respiratory tract infections in children with intrauterine smoke exposure
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 427
OP 431
DO 10.1136/adc.2009.162685
VO 95
IS 6
A1 Jopje Ruskamp
A1 Henriette Smit
A1 Maroeska Rovers
A1 Maarten Hoekstra
A1 Anne Schilder
A1 Bert Brunekreef
A1 Alet Wijga
A1 Marjan Kerkhof
A1 Johan de Jongste
A1 Elisabeth Sanders
YR 2010
UL http://adc.bmj.com/content/95/6/427.abstract
AB Background Exposure to environmental tobacco smoke (ETS) is known to increase the risk of respiratory tract infections (RTI). Some children, however, may be more susceptible to the harmful effects of ETS than others. We examined whether early atopic status (defined by elevated neonatal total IgE (tIgE) or symptoms of atopic dermatitis) modified the association between ETS exposure and RTI. Methods The data of 2863 children from the Prevention and Incidence of Asthma and Mite Allergy birth cohort were collected to the age of 4 years. Neonatal tIgE was collected from a subset of 914 children, and clinical information by yearly parental questionnaires. The effect of pre- and/or postnatal ETS exposure, early atopic status and interaction between these factors was studied for various RTI. Results Children with elevated tIgE or atopic dermatitis and prenatal ETS exposure have a strongly increased risk of frequent RTI (aOR 6.18 (95% CI 1.45 to 26.34) and 5.69 (2.01 to 16.04), respectively; interaction p=0.006 and p=0.14, respectively) compared to non-atopic children without prenatal ETS exposure. Similar results were seen for lower RTI and otitis. This effect was less evident for postnatal ETS. Conclusion Early atopic status enhances the risk of RTI in children with prenatal ETS exposure. This suggests that host factors modify the association between ETS and RTI.