PT - JOURNAL ARTICLE AU - Woolf Walker AU - Robert Wheeler AU - Julian Legg TI - Update on the causes, investigation and management of empyema in childhood AID - 10.1136/adc.2009.165357 DP - 2011 May 01 TA - Archives of Disease in Childhood PG - 482--488 VI - 96 IP - 5 4099 - http://adc.bmj.com/content/96/5/482.short 4100 - http://adc.bmj.com/content/96/5/482.full SO - Arch Dis Child2011 May 01; 96 AB - Despite being recognised for over two millennia and having an increasing incidence in many countries, the management of childhood empyema remains controversial. This review examines the recent literature on its causes and investigation then focuses on its treatment. Following a trial of appropriate intravenous antibiotics, the evidence would currently support the use of chest drain insertion with urokinase instillation as first line treatment with video-assisted thoracoscopic surgery to be used for failure of medical management. A treatment algorithm is proposed to guide clinical practice.