RT Journal Article SR Electronic T1 Ethical issues of clinical trials in children: a European perspective JF Archives of Disease in Childhood JO Arch Dis Child FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health SP 474 OP 477 DO 10.1136/adc.2008.149898 VO 94 IS 6 A1 Sammons, H YR 2009 UL http://adc.bmj.com/content/94/6/474.abstract AB Children should not be harmed by their participation in clinical trials, therefore should no clinical trials be performed? This is a view that needs to be balanced as clinical trials provide the evidence we need to allow children safe and effective prescribing of medicines. Therefore, is it unethical not to involve this population in research? This review looks at new ethical guidance released to support the recently introduced European legislation for the licensing of medicines.