RT Journal Article
SR Electronic
T1 Association between birth weight and adolescent systolic blood pressure in a caucasian birth cohort differs according to skin type, CRH promoter or 11β-HSD2 genotype
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 760
OP 767
DO 10.1136/adc.2007.129122
VO 93
IS 9
A1 Dwyer, T
A1 Blizzard, L
A1 Patterson, B
A1 Ponsonby, A-L
A1 Martin, K
A1 Quinn, S
A1 Sale, M M
A1 Richards, S M
A1 Morley, R
A1 Rich, S
A1 Dickinson, J L
YR 2008
UL http://adc.bmj.com/content/93/9/760.abstract
AB Objective: To examine whether the inverse association between birth weight and blood pressure varies by skin pigmentation and/or related genotypes.Study design: 671 children from a predominantly caucasian birth cohort were followed-up to adolescence (mean (SD) age 14.4 (0.64)).Methods: Data on birth weight, socioeconomic status, maternal antenatal smoking, adolescent blood pressure and polymorphisms of candidate genes were obtained and analysed by multiple linear regression.Results: An increase in birth weight of 1 kg was associated with an non-significant difference in adolescent systolic blood pressure of –0.53 mm Hg (95% CI –1.72 to 0.66) per kg after adjustment for child age and cohort entry criteria. The inverse association between birth weight and systolic blood pressure was stronger for those with darker skin (⩾2% melanin) (difference in effect, p = 0.02), those with more copies of the C allele of corticotropin-releasing hormone (CRH) +T1273C (p = 0.06), and those with more copies of the short (⩽236 bp) form of the 11β-HSD2{CA}nrepeat microsatellite (p = 0.03).Conclusions: These findings add to the evidence that cortisol-related pathways may account for at least part of the observed birth weight–blood pressure associations.