TY - JOUR T1 - Plenary JF - Archives of Disease in Childhood JO - Arch Dis Child SP - A1 LP - A8 VL - 94 IS - Suppl 1 A2 - , Y1 - 2009/03/01 UR - http://adc.bmj.com/content/94/Suppl_1/A1.abstract N2 - 1H. Spiers, 1J. Van Limbergen, 1R. Farhadi, 2R. Russell, 1M. Wilson, 3H. Drummond, 4G. Mahdi, 3J. Satsangi, 1D. Wilson. 1Child Life and Health, University of Edinburgh, Edinburgh, UK, 2Paediatric Gastroenterology, Yorkhill Hospital, Glasgow, UK, 3Gastrointestinal Unit, Western General Hospital, University of Edinburgh, Edinburgh, UK, 4Paediatric Gastroenterology, Ninewells Hospital, Dundee, UKBackground and aims: The incidence of inflammatory bowel disease (IBD) is increasing among children in Scotland yet the aetiology of IBD remains largely unknown. Genetic and environmental risk factors have been implicated. We have shown (1) that the phenotype of childhood-onset IBD is more extensive than adult-onset IBD in Scotland, and also (2) that the carriage of variants of genes implicated in IBD susceptibility does not differ between these Scottish IBD populations. We aimed to investigate the influence of a range of potential environmental factors in the development of paediatric IBD.Methods: 126 cases of paediatric IBD (diagnosed <17 years of age; median age at diagnosis 9.8 years (Q1–Q3: 7.5–11.7)) were each matched with one control subject by age, sex and geographical location (to match for socio-economic status); controls were obtained by the general practitioner of each case. Children with IBD and their parents were interviewed face-to-face to obtain data on breastfeeding, immunisation history, surgical and medical history and family history (FH). Control data were obtained via postal questionnaire. Unifactorial analyses using the χ2-test and multifactorial analysis using binary logistic regression were performed.Results: FH of IBD was associated with IBD (OR 3.34; 95% CI 1.70 to 6.56; p = 0.0003). History of asthma (OR 2.48; 95% CI 1.28 to 4.78; p = 0.005), eczema (OR 2.83; 95% CI 1.50 to 5.36; p = 0.001) and food allergy (OR 2.98; 95% CI 1.04 to 8.54; p = 0.03) show a significant association with … ER -