TY - JOUR T1 - Weight gain with pizotifen therapy JF - Archives of Disease in Childhood JO - Arch Dis Child SP - 590 LP - 593 DO - 10.1136/adc.2007.128611 VL - 93 IS - 7 AU - G L Briars AU - S E Travis AU - B Anand AU - A M Kelly Y1 - 2008/07/01 UR - http://adc.bmj.com/content/93/7/590.abstract N2 - Objective: To describe the characteristics of weight gain occurring in children treated for migranous conditions with pizotifenDesign: Retrospective case note reviewSetting: West Suffolk Hospital between 1999 and 2003Patients: 405 clinic attendances of 121 children receiving pizotifen treatmentMain outcome measures: Rates of change in weight for age z score between successive outpatient appointments were used to detect excessive weight gain.Results: The mean rate of weight z score increase for 105 patients receiving a constant dosage in 181 intervals between appointments was 0.79 standard deviations per year compared with 0.11 standard deviations per year for height z score increases. The rate of weight z score increase was not correlated with pizotifen dose per kg (r = −0.08), per m2 (r = −0.05) or initial body mass index (r = −0.04). Mean rates of z score increase were similar in patients with a satisfactory and unsatisfactory therapeutic responses.Conclusions: Excess weight gain in pizotifen therapy is not predicted by drug dosage or therapeutic response within the range of doses used in clinical practice. ER -