RT Journal Article
SR Electronic
T1 Very prematurely born infants wheezing at follow-up: lung function and risk factors
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 776
OP 780
DO 10.1136/adc.2006.112623
VO 92
IS 9
A1 Simon Broughton
A1 Mark R Thomas
A1 Louise Marston
A1 Sandra A Calvert
A1 Neil Marlow
A1 Janet L Peacock
A1 Gerrard F Rafferty
A1 Anne Greenough
YR 2007
UL http://adc.bmj.com/content/92/9/776.abstract
AB Objectives: To determine whether abnormalities of lung volume and/or airway function were associated with wheeze at follow-up in infants born very prematurely and to identify risk factors for wheeze.Design: Lung function data obtained at 1 year of age were collated from two cohorts of infants recruited into the UKOS and an RSV study, respectively.Setting: Infant pulmonary function laboratory.Patients: 111 infants (mean gestational age 26.3 (SD 1.6) weeks).Interventions: Lung function measurements at 1 year of age corrected for gestational age at birth. Diary cards and respiratory questionnaires were completed to document wheeze.Main outcome measures: Functional residual capacity (FRCpleth and FRCHe), airways resistance (Raw), FRCHe:FRCpleth and tidal breathing parameters (TPTEF:TE).Results: The 60 infants who wheezed at follow-up had significantly lower mean FRCHe, FRCHe:FRCpleth and TPTEF:TE, but higher mean Raw than the 51 without wheeze. Regression analysis demonstrated that gestational age, length at assessment, family history of atopy and a low FRCHe:FRCpleth were significantly associated with wheeze.Conclusions: Wheeze at follow-up in very prematurely born infants is associated with gas trapping, suggesting abnormalities of the small airways.