@article {Kitchin11, author = {N R E Kitchin and J Southern and R Morris and F Hemme and S Thomas and M W Watson and K Cartwright and E Miller}, title = {Evaluation of a diphtheria{\textendash}tetanus{\textendash}acellular pertussis{\textendash}inactivated poliovirus{\textendash}Haemophilus influenzae type b vaccine given concurrently with meningococcal group C conjugate vaccine at 2, 3 and 4 months of age}, volume = {92}, number = {1}, pages = {11--16}, year = {2007}, doi = {10.1136/adc.2005.076109}, publisher = {BMJ Publishing Group Ltd}, abstract = {Background and objective: In view of the possible introduction of diphtheria{\textendash}tetanus{\textendash}acellular pertussis{\textendash}inactivated poliovirus{\textendash}Haemophilus influenzae type b (DTaP-IPV-Hib, eg Pediacel) vaccine in the UK, a study of the immunogenicity of Pediacel when given with one of two different meningococcal group C conjugate (MCC) vaccines at 2, 3 and 4 months of age was conducted. Methods: Randomised controlled study in 241 infants. Results: Post vaccination, the proportion of infants with anti-polyribosylribitol phosphate (PRP) levels ⩾0.15 μg/ml was 93.2\% (95\% confidence interval (CI) 86.6 to 96.7) in the Pediacel group compared with 100\% (95\% CI 96.4 to 100) in the diphtheria{\textendash}tetanus{\textendash}whole-cell pertussis{\textendash}Haemophilus influenzae type b (DTwP-Hib) group. The anti-PRP response was lower in infants receiving either Pediacel or DTwP-Hib when these vaccines were given concomitantly with meningococcal group C conjugate with diphtheria-derived protein CRM197 as conjugate protein (MCC-CRM) compared with meningococcal group C conjugate with tetanus toxoid as conjugate protein (MCC-TT). For group C meningococcus, the proportion of infants with serum bactericidal antibody (SBA) titre ⩾1:8 in the Pediacel group was 99.0\% compared with 100\% in the DTwP-Hib group. The MCC SBA geometric mean titre (GMT) was lower in those receiving Pediacel with MCC-TT than in those receiving DTwP-Hib with MCC-TT, although all titres were well above the protective threshold. The MCC SBA GMT was similar in those receiving Pediacel and DTwP-Hib and MCC-CRM. Responses to all other vaccine components were equivalent in the two groups. Conclusions: Pediacel is immunogenic when given at 2, 3 and 4 months of age. Coadministration of MCC vaccine can influence the Hib response, and the MCC response to a tetanus conjugate can be influenced by the nature of the coadministered DTP-Hib vaccine.}, issn = {0003-9888}, URL = {https://adc.bmj.com/content/92/1/11}, eprint = {https://adc.bmj.com/content/92/1/11.full.pdf}, journal = {Archives of Disease in Childhood} }