RT Journal Article SR Electronic T1 Understanding systematic reviews and meta-analysis JF Archives of Disease in Childhood JO Arch Dis Child FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health SP 845 OP 848 DO 10.1136/adc.2004.058230 VO 90 IS 8 A1 A K Akobeng YR 2005 UL http://adc.bmj.com/content/90/8/845.abstract AB This review covers the basic principles of systematic reviews and meta-analyses. The problems associated with traditional narrative reviews are discussed, as is the role of systematic reviews in limiting bias associated with the assembly, critical appraisal, and synthesis of studies addressing specific clinical questions. Important issues that need to be considered when appraising a systematic review or meta-analysis are outlined, and some of the terms used in the reporting of systematic reviews and meta-analyses—such as odds ratio, relative risk, confidence interval, and the forest plot—are introduced.